Apolipoprotein L1
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Search complete. 9 mentions across 4 episodes found for "Apolipoprotein L1".
Sep 28, 2026
Alex MercerHOST
Still in kidney disease, but much earlier in development, with a story we reported Wednesday.
Alex MercerHOST
Vertex reported Phase 2b amplified results for inaxiplin, its investigational once-daily drug for APOL1-mediated kidney disease.
Alex MercerHOST
For Vertex, the telling part is who was studied.
Maya PatelHOST
Vertex describes these as additional populations that its pivotal amplitude trial isn't covering.
Laurel WilligGUEST
Well, I think that you might get differing answers from different people on that question.
Laurel WilligGUEST
I think there is a lot of evidence to suggest in certain types of APOL1-mediated kidney disease, there is a second hit that kind of leads to the development of renal disease, but there is also evidence to suggest that genetic background and those kinds of things may also lead to the development of kidney disease and explain some of the variable presentations of renal disease within APOL1.
Laurel WilligGUEST
So I don't think we 100% know the answer to that question at this point in time.
Laurel WilligGUEST
But I think people have sort of moved forward in the field with targeting not the second hit per se in some of the diseases, but instead targeting the downstream effects.
7 MINS LATER
Laurel WilligGUEST
specifically ones that target APOL1 proteins.
Laurel WilligGUEST
It will be important to label, I think, those diseases as being mediated by that.
Laurel WilligGUEST
But I do think they may be different enough physiologically that we may want to have subcategories within the big lump of APOL1-mediated kidney disease.
Jason MisuracHOST
Right, because when it comes along with HIV or some other diagnosis, you're going to also always be treating the underlying diagnosis.
Alex MercerHOST
Staying in kidney disease, Vertex's update is about who else its drug might reach.
Alex MercerHOST
Yesterday, it reported Phase IIb results for oral inexaplin in APOL1-mediated kidney disease tied to inherited gene variants and concentrated in people of African ancestry.
Alex MercerHOST
This smaller study examines two groups outside its separate pivotal trial, people with more modest protein leakage and a separate group with type two diabetes.
Maya PatelHOST
diabetes.In the first group, the amount of the protein albumin in urine fell about forty-three percent from baseline at week thirteen.
Holly ThackerHOST
because initially probably with evolution, there was a protective mechanism to this, you know, just like many Africans have the sickle cell gene, which helped them not get malaria as much.
Holly ThackerHOST
Many blacks also have APO-L, which is an increased risk for renal disease, but it had a protective mechanism against sleeping sickness.
Holly ThackerHOST
So it's very interesting to look at genetics and how that has evolved and how that can influence disease, but clearly there is an environmental and genetic interaction.
Holly ThackerHOST
And as I was mentioning that Nigerians have a very, very high rate of ApoE4, Nigerians in Nigeria don't have the dementia that we have in the United States.