Antibody-dependent cellular cytotoxicity

But especially for dengue, where neutralization is in the eye of the beholder, and neutralizing the antibody can be neutralizing at one concentration but enhancing at another concentration, Looking at other functions of the antibody is really important for understanding the full picture of the immune response.

Looking at things like antibody-dependent cellular toxicity, ADCC, antibody-dependent cellular phagocytosis, how well do these antibodies facilitate these other effector functions, as well as the distribution of the different antibody isotypes.

One of the areas of interest in my lab, outside of this B-cell infection phenomenon, is the contribution of IgA to the pathogenesis of dengue, or black thereof.

This harkens back to an observation that's been recapitulated by multiple great studies that patients with milder dengue disease, have a unexpectedly large amount of IgA, dengue-specific IgA.

That is then going to bind to our target cell and the immune system recognizes bound antibody for then immune-mediated cytotoxic cell clearance.

So it's called ADCC, antibody-dependent cell clearance.

So what we're really doing is saying these cells here exclusively in the vasculature are expressing this target and only after they transform senescence.

That's going to reduce the safety hazards because we're not targeting any of the other senescent cells as well, including the heart, brain, testes, anything like that.