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Androgen replacement therapy

Androgen replacement therapy

Search complete. 1013 mentions across 231 episodes found for "Androgen replacement therapy".

Oct 26, 2026

Derek MunroGUEST
4:32
It's a long ester, and you are not having any dips following a diurnal rhythm through normal pulsatile secretions, which happens endogenously when you have natural testicular output of testosterone.
Derek MunroGUEST
4:43
Normally, you would have test levels go up in the morning, and they would dip, kind of like go up and down, up and down, and you would not have a disproportionately high free T. Testosterone that is supporting enhanced amounts of muscle mass, whereas when you're on exogenous TRT, even if you have your training twice a day or you're getting shitty sleep or you go out drinking or whatever it is like your level stay exactly where you want them to.
Derek MunroGUEST
5:08
They don't dip.
Derek MunroGUEST
5:09
They don't change.
Derek MunroGUEST
7:17
It very much depends on what achieves symptom relief, what your levels...
Derek MunroGUEST
7:21
Again, the levels on a piece of paper are kind of just arbitrary at the end of the day.
Derek MunroGUEST
7:25
It's about what – if you had primary hypogonadism and you needed TRT, whatever gets you to symptom relief is probably what you need, even if it – some guys need more than what Liver King takes in testosterone dose.
Derek MunroGUEST
7:40
But I'm just saying that the context in which he presents it very much implies that – Previous to even the request for how do I optimize my IGF-1 and take, you know, why is the GH not doing what I think it's going to do? There was, to build the physique where he got, like, there was blasting involved.
Derek MunroGUEST
1:39
Yeah.
Derek MunroGUEST
1:39
And it's like, while I do totally understand the benefits of TRT and, you know, HRT and having proper medical oversight, et cetera, like some of the justifications for like DECA and Winstrel and stuff that is clearly only included to enhance your image to like in your 40s, there's nothing ancestral or conducive to longevity about adding in Winstrel.
Derek MunroGUEST
2:03
Like, let's be fucking honest.
Derek MunroGUEST
2:04
So, when he said it didn't help, it's just like, well, what was the desired outcome of it to begin with?
StevesmiHOST
49:57
again.
MobsterHOST
49:58
So something you brought up, which we were kind of interested in, right? So at some point, I'm assuming, and you can tell us what happened, you've looked at TRT.
MobsterHOST
50:07
And one of the things that came up when you were looking at TRT was was this bizarre issue of where you lived versus if you lived a little bit closer to the state line, as you said in your show notes, making it easier for you to get a prescription.
MobsterHOST
50:21
So talk about first thinking about CLT and then this particular state line issue in regards to getting a prescription.
MobsterHOST
50:28
Yeah.
grokSCGUEST
51:08
I was in my late 40s and I was still in really good condition.
grokSCGUEST
51:12
And I was like.
grokSCGUEST
51:14
when I turned 50, I'm going to go to the TRT clinic and go ahead and get on TRT.
Karan RajanHOST
32:57
i mean this is not a direct study based on what we've discussed on testosterone but i came across an interesting piece of maybe adjacent research uh it was an integrated analysis of over 1500 men exposed to androgen-based male contraceptive regimens and they found that actually the recovery to a sperm concentration of 20 you know million per mil occurred in approximately 67% by six months, 90% by 12 months, 96% of men by 16 months, and then eventually all the men had returned to at least that normal sperm count by around 24 months in those trial populations.
Karan RajanHOST
33:34
And I think, you know, it's worth noting that obviously these were controlled male contraceptive studies, you know, generally involving healthy men, not necessarily people who have taken TRT and anabolic steroid for years, but maybe that is some sort of proxy that can warn recovery, you know, that it can take months, if not years of recovery, if you're abusing steroids or taking it inappropriately.
Channa JayasenaGUEST
33:59
Yeah, and we're increasingly finding there's an interesting divergence so that if you particularly take what we would all call steroids, roids, with very, very strong high doses, there's a concern that it could in some cases take...
Channa JayasenaGUEST
34:17
Most men will recover within 12 months, but in some, there's a possibility that it could take years.

6 MINS LATER

Channa JayasenaGUEST
39:55
But if you take it excessively, it's likely to worsen your health.
Karan RajanHOST
40:00
Now, we spoke before about the risks of diabetes.
Karan RajanHOST
40:04
short, medium, and maybe even long-term infertility by inappropriately using TRT and testosterone and these other hormones.
Karan RajanHOST
40:12
Now, I don't know why, but I often see this strong correlation between, or sometimes men interchangeably assuming that testosterone equals sperm health and sperm health equals testosterone.
Geo EspinosaHOST
28:18
also what matters to the patient, right? Some patients, even as an example, Jim, they go on ADT, right? And then you go for several years and say, this is horrible.
Geo EspinosaHOST
28:28
So you know what? I'm actually going to do TRT.
Geo EspinosaHOST
28:31
I'm going to do testosterone replacement therapy.
Geo EspinosaHOST
28:34
And that's not that off, by the way, even with the current science.
Scott McNallyHOST
40:57
Then it became more off than on until 40, and I've been consistently in the gym and the kitchen since.
Scott McNallyHOST
41:10
I'm now almost 44 and on TRT only, 100 milligrams a week.
Scott McNallyHOST
41:15
I was...
Scott McNallyHOST
41:19
You know what happens when you have a really long message and
Skip HillHOST
46:00
I would ask, I'd tell the guy this video, take a video.
Skip HillHOST
46:04
of your where we can see your breathing because I would love to assess it based on a video but I would say do it from the front and I would say also do it a little bit from the side because we may need the side profile to see what your stomach even if you have a belt on your gut and your rib cage will see something in there and be able to give you I think better feedback than just trying to wonder what does it look like what is this rep tempo things like that
Scott McNallyHOST
46:31
yeah well I use test sip because that's what my TRT clinic prescribes.
Scott McNallyHOST
46:39
In a bodybuilding context, when we implement other test esters in Y, siponate, anethate, proponate, undecanoate, suspension, sustenon.
Robert BreedloveGUEST
11:59
And so I actually have a good story about that, because for me, I'll try to answer your question more directly, but I want to share this first.
Robert BreedloveGUEST
12:06
When I started taking TRT.
Robert BreedloveGUEST
12:09
Actually, I didn't have many of the issues.
Robert BreedloveGUEST
12:11
I was okay in the gym.

10 MINS LATER

Robert BreedloveGUEST
22:17
I mean, not uncommon, but it's more rare for a guy to be on testosterone now, I would say, than not.
Robert BreedloveGUEST
22:24
I think that will invert.
Robert BreedloveGUEST
22:25
You know, I think most guys over 40 will be on some form of TRT or anabolic in the next 10 or 20 years.
Robert BreedloveGUEST
22:31
I'd buy that.
Jason MahoneyHOST
16:05
And it seems like
Dave FarraHOST
16:06
specifically with women, because I mean, we've heard about like for guys like TRT for a long time.
Jason MahoneyHOST
16:10
That's been around for at least, you know, I mean, you and I have been, you know, as long as we've been, you know, having TRT pitched at us for probably 15 years.
Jason MahoneyHOST
16:18
And 15 at least.
Jason MahoneyHOST
16:19
Yeah.
Michael FarberGUEST
6:50
I'm not going to go and take anabolics.
Michael FarberGUEST
6:52
I take a baseline of TRT at 75, your testosterone does start to decline.
Michael FarberGUEST
7:00
And one of the reasons is because it's such a small molecular structure compared to folistatin itself, or even compared to the molecular antibodies that other companies try to do.
Michael FarberGUEST
7:13
So its penetration is much better, and it's turned out to be a very effective myostatin inhibitor.
Jamie DorleyHOST
1:15
Well, that's interesting because we're going to be talking about endocrine solutions and hormones right now.
Jamie DorleyHOST
1:22
And this is probably one of the hottest topics out there these days from TRT to pellets to injections to GLP-1s and all these different things that people are so into now.
Jamie DorleyHOST
1:36
It wasn't that long ago that people were actually like totally against hormones.
Jamie DorleyHOST
1:40
So what we want to do is we want people to get the maximum results possible.

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