American Journal of Respiratory and Critical Care Medicine

But times they are a-changing.

In recent years, the merit of this adjustment for ethnicity has been debated in major reviews in the European Respiratory Journal, Chest, and the American Journal of Respiratory and Critical Care Medicine.

That perhaps it's not race that drives population differences but other modifiable factors.

Or if there is some pre-existing difference, this needs to be explored also in overlooked groups such as First Nations people.

Orexin, so the neuropeptide produced in the lateral hypothalamus responsible for wakefulness and upper airway muscle tone, by the way, becomes dysregulated.

Twenty twenty American Journal of Respiratory and Critical Care Medicine showed orexin A levels in OSA patients significantly suppressed during sleep, reducing the very signal that should be doing what? Keeping your airway muscles engaged.

Your body's not failing randomly, it's failing sequentially, systemically, and predictably.

But you think sleep a- and then, and here's the thing too, I...

Welcome to the show.

Today we are looking at a brand new, highly provocative 2026 randomized clinical trial published in the American Journal of Respiratory and Critical Care Medicine.

A fantastic paper.

Yeah, it's really interesting.