Alkaline phosphatase

It can neutralize endotoxins, which in general, there's these bacterial lipopolysaccharides, LPSs, which are endotoxins, and they can cross a leaky intestinal barrier and cause like autoimmune reactions, metabolic syndrome, you name it.

So these alkaline phosphatases or ALP can actually neutralize those endotoxins in your gut lumen.

And that helps to safeguard your tight junction integrity.

Well, pasteurization just denatures them.

Yeah, you should give a seminar on picking your handle.

ALT 130, GGT 130, ALP 250, A1C 5.4, liver ultrasound normal, no hepatitis, no booze, no NSAIDs, or CHF.

Stopped statin about six months ago, no change.

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And at least in my mind, that's one of the reasons why some of those patients some of the blood tests can be normal.

The other blood test that we look at is the blood test called the alkaline phosphatase or ALP.

The problem with the alkaline phosphatase is that while it can often indicate that there might be a problem with the liver and particularly with how the bile flows out of the liver, usually into the gallbladder if you have one, if not into the intestines, but when those bile ducts are irritated, that particular enzyme can be up.

And there are a lot of diseases that we look for when it is up.

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Alkaline phosphatase or ALP.

Normal range is 40 to 130 units per liter.

Alkaline phosphatase is a protein that's found in every body tissue, but mostly where you're going to see it is liver, intestines, biliary tract, bones, and placenta.

But the highest concentrations of ALP or alkaline phosphatase are going to be found in the bone and the liver.

And what the test measures, why we run this ALP, is it measures the level of ALP that's actually in the blood.

So most often, this test is run to detect for conditions of liver disease or bone disorders.

What will happen if there's a condition that affects the liver is that the liver cells will actually release higher levels of ALP into the blood.

We'll look at waist circumference if needed in that particular, if it makes sense in that context.

and maybe liver markers as well, like bilirubin, ALT, AST, ALP, GGT.

These are things you might see on blood work if you get copies of them from your GP.

And then potentially other investigations, depending on your personal and family history.

The GGT acts as the ultimate tiebreaker.

You would also look at alkaline phosphatase, or ALP, which behaves similarly to GGT in ruling out exertional cholestatic injury.

If GGT and ALP are normal, the diagnosis shifts entirely from liver failure to extreme muscle trauma.

It dictates a completely different treatment path.

That is such an empowering piece of knowledge for both athletes advocating for themselves and for medical staff at these remote races.

So there's a bunch of letters in there.

Three of the letters that you'll see in there is ALP, which is alkaline phosphatase.

Sometimes you might see it spelled out as alkaline phosphatase.

Sometimes you might see ALPhos.

Sometimes you see ALP.

Now, that is what bone-specific alkaline phosphatase is, except bone-specific means that that ALP was spun down.

Mm-hmm.

Because the ALP on the complete metabolic profile and the code letters for that lab are CMP.

So they almost exclusively have elevated liver enzyme.

And very interesting enough, it's not just ALT, but often we also see ALP and also total bilirubin being increased.

And I have several case that we follow the blood tests like along the way, you know, like before, during, after treatment, and we realized that the bilirubin will actually continue to increase until you surgically resolve it, and then it will start to drop.

So that's what we see here.