Alanine transaminase
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Search complete. 76 mentions across 19 episodes found for "Alanine transaminase".
Sep 17, 2026
Paul MasonHOST
The other thing that we're going to reliably see is an increase in a chemical called alanine aminotransferase.
Paul MasonHOST
This is ALT.
Paul MasonHOST
Now this is often synonymously used to indicate fatty liver.
Paul MasonHOST
And I do take a bit of issue with that.
Paul MasonHOST
I feel the term fatty liver is quite pejorative.
Paul MasonHOST
And I feel that just because we see this increase in ALT enzyme, it's not proof that your liver is fatty.
Paul MasonHOST
Now they often do go together.
Paul MasonHOST
They do often associate together.
Dr. MJ CollierCORRESPONDENT
Every time you go to the doctor, there's a test called a comprehensive metabolic panel or CMP that includes liver enzymes.
Dr. MJ CollierCORRESPONDENT
It includes, uh, one called an alkaline phosphatase, the AST and the ALT.
Dr. MJ CollierCORRESPONDENT
Uh, those can be abnormal in fatty liver, but also the, the most diagnostic test is an ultrasound.
Dr. MJ CollierCORRESPONDENT
But if you are overweight, you can have fatty liver.
Dr. MJ CollierCORRESPONDENT
Every time you go to the doctor, there's a test called a comprehensive metabolic panel or CMP that includes liver enzymes.
Dr. MJ CollierCORRESPONDENT
It includes, uh, one called an alkaline phosphatase, the AST and the ALT.
Dr. MJ CollierCORRESPONDENT
Uh, those can be abnormal in fatty liver, but also the, the most diagnostic test is an ultrasound.
Dr. MJ CollierCORRESPONDENT
But if you are overweight, you can have fatty liver.
Leslie KernisonHOST
They may have already been done for you in recent years.
Leslie KernisonHOST
Sign number four is AST and ALT climbing.
Leslie KernisonHOST
These blood tests reflect enzymes in liver cells and they go up when liver cells are under strain because when the liver cells are under strain, they start to leak these enzymes.
Leslie KernisonHOST
The liver cells might even break open and release these enzymes into the bloodstream.
Leslie KernisonHOST
So this is important because the liver metabolizes most medications and all alcohol.
Leslie KernisonHOST
So for instance, we can often see AST and ALT go up if somebody has just had a few nights of heavy drinking.
Leslie KernisonHOST
We'll see a bump in there.
Leslie KernisonHOST
If they're taking a medication that is putting the liver under strain, that will also increase these.
LeraPANELIST
Creatinine was a bit higher than his baseline at 1.35, with his baseline around one.
LeraPANELIST
For liver function test, ALT was 31, AST was 41, alkaline phosphatase 96, and TBL was 0.7, so basically all normal.
LeraPANELIST
Albumin was 3.6 with total protein of 6.6, and CRP was 86, with normal in our lab being less than 10.
LeraPANELIST
Urinalysis was also checked, so specific gravity was a bit higher.
10 MINS LATER
AlecHOST
I think that can give you clues as the disease evolves.
AlecHOST
And then as the pattern of the labs evolves, that can help, you know, filter your differential diagnosis as well.
AlecHOST
So for example, if thrombocytopenia becomes more prominent and AST and ALT go up, perhaps you're gonna entertain the idea of more tick-borne illnesses.
AlecHOST
And so on and so forth, however you play it.
JoshGUEST
Okay.
JoshGUEST
A-L-T, the L in that, we're going to associate that L with the liver, meaning A-L-T is more liver-specific, meaning if you drink alcohol or you take Tylenol or anything, A-L-T is going to be the primary liver enzyme that moves.
JoshGUEST
A-S-T will as well, but A-L-T, anytime you think A-L-T, think liver.
JoshGUEST
AST, okay, which is a different liver enzyme still found in the liver, whereas AST primarily found outside the liver, skeletal muscle.
speaker_2UNKNOWN
So
RezaHOST
100% normal.
RezaHOST
Now his AST is like 167, ALT is like 80-
RabihHOST
Mm
RezaHOST
... alk phos is 300-
RezaHOST
They said, "In reading the ortho note, there was a lot of ma- manipulation of both muscle and bone."
RabihHOST
Oh, interesting.
RezaHOST
"There is a possibility that the AST and ALT reflect muscle and that the alk phos reflects the skeleton from the manipulation.
RezaHOST
Send a CK and send a GGT."
Damian ChaparroHOST
So we were so happy to have good news about drinking that we mostly ignored the rest of the graph.
Damian ChaparroHOST
If you want to know how your drinking has impacted your body, the clearest single metric is called ALT, or alanine aminotransferase.
Damian ChaparroHOST
If your liver's ALT score is above 19 units per liter for women or 30 units per liter for men, you could have early fatty liver disease without any obvious symptoms.
Damian ChaparroHOST
In fact, about a third of the population is walking around with early stage fatty liver.
Damian ChaparroHOST
One test, which includes ALT along with six other important measures, can be taken from home and is more important than anything we'll really discuss today because it tells you exactly how your drinking might be impacting your liver.
Damian ChaparroHOST
You can just search Adarha Longevity Labs or have a look at the link in the description and you can order one of these tests to show up at your door.
Damian ChaparroHOST
Now, the second graph, this graph should be on every bottle of alcohol.
Axay ShahGUEST
So even my liver changes.
Axay ShahGUEST
Generally, the liver enzyme is ALT.
Axay ShahGUEST
It gives you that the mark, it gives you whether what is the health of your liver.
Axay ShahGUEST
So at age 50, it was in 2009, I had 40, 40, that number, ALT number.
Axay ShahGUEST
It's supposed to go more, 40 to 45 as you age, 45 to 50, whatever, it goes more.
Axay ShahGUEST
Now, in 2025, that ALT from 40 become 21.
Axay ShahGUEST
I reversed it.
Axay ShahGUEST
You reversed it.
Joe PizzornoGUEST
Next thing I'd like to do is I'd like to look at how much damage is being done to the liver.
Joe PizzornoGUEST
So I look at ALT.
Joe PizzornoGUEST
Now, again, I'm looking at ALT.
Joe PizzornoGUEST
Well, the standard is up to 30.
Joe PizzornoGUEST
Well, anything ALT, anything above 20 indicates the liver is
Ben WeitzHOST
being damaged.
Ben WeitzHOST
Okay.
Ben WeitzHOST
And then the final one.
9 more episodes mention Alanine transaminase.
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