Akkermansia muciniphila

And it wasn't until I replaced aggressively their vitamin D that we were able to make real strides in healing their leaky gut.

High levels of vitamin D mean you have more butyrate producing bacteria and more of one of my favorite gut buddies like Akkermansia muciniphila.

Now, don't shun the sun completely.

Get outside, but don't delude yourself into thinking that all you need is vitamin D from the sun.

It's a starch which is called inulin.

And inulin is, has been found in recent years to be a very important, um, provocation to an important gut microbiome denizen which is called Akkermansia muciniphila, and is thought to be, it's known, not thought, to be a keystone species, so important in driving gut microbiome health that you'll now see, like Dr. William Lee.

Have you ever had him on your show?

A lot.

Um, but you know, eating these, I like eating these, uh, dandelions a few times a week because th- it has all this inulin which really, um, gets them to grow well in your gut.

And the other thing I like to do is the sunchokes have even a greater amount of this inulin.

And so I combine them together and I eat them, and I always think, so I'm supporting my Akkermansia muciniphila.

Boy, beautiful.

[laughs] And now, there's this new bacteria that I'm noticing that's missing in a lot of people's gut, and it's called Akkermansia.

Akkermansia, the full name is Akkermansia muciniphila, but it lives in the mucus layer of the gut.

So, it lives right here, next to these enterocytes, and it creates that protective mucus that, you know, prevents leaky gut.

But if you're missing this critical bacteria that's making the mucus, well, you're definitely higher risk of leaky gut.

Yeah.

So the, the strains that we have that we've extracted, like Dr. Coetzee said, from a human donor is Akkermansia muciniphila, Faecalibacterium prausnitzii or F. prau, and Roseburia, and then two other different forms of bifidobacteria that work with the cross-feeding and everything like that.

So because they come from the human donor, they grew up together, they have this sense of p- community, they work well off of each other, uh, they kind of work as a team.

So they do have the potential to engraft, which means that you only need to take them for m- for, like, three months or something like that.

Let me assure you that all seed oils are not the evil empire.

In fact, perilla seed oil has been shown to encourage the growth of my favorite gut buddy, that keystone species, Akkermansia muciniphila, one of the most important gut bacteria to support your intestinal lining.

And as you know, a healthy intestinal lining means less inflammation, which can help your brain function more clearly.

It also has rosmarinic acid.

A traditional gastroenterologist or synthetic peptide researcher would argue two things.

First, they would claim that Akkermansia muciniphila is a mucin-degrading bacterium, and if over-promoted without adequate dietary fiber, it could theoretically thin the protective mucus l- layer excessively and worsen colitis.

Second, they would argue that synthetic GLP-1 receptor agonists are potent biological anti-TNF agents, reduce systemic inflammation faster and more reliably than microbial SCFA modulation.

Both of those land pretty well, Ted.

So starve...

If we work backward here, bacterial LPS is crossing into the bloodstream, right? That's because oxygen's leaking into the gut, and that's because the colonocytes that rely on butyrate, when they're starved, they flip to anaerobic glycolysis.

Second, Akkermansia muciniphila is not just another gut microbe.

It is the master regulator of the mucosal shield.

Are there other natural supplements that have an effect?

There's been some discussion that targeting the, uh, gut bacteria, uh, has an effect on raising GLP-1, part- in particular, uh, one organism called Akkermansia muciniphila that I'm sure you're familiar with.

So we're, we're seeing some data that Akkermansia is effective in increasing GLP-1, and, uh, certainly, uh, that's, uh, a marketing, uh, has been looked at in the marketing of, uh, the Akkermansia products that we see available.

Uh, there is evidence, though, that Akkermansia does increase GLP-1.

Uh, akkermansia is a bac- is, is a, a type of-

Yeah

... bacterium that enriches, uh, you, you want to enrich the levels of this akkermansia muciniphila, uh, in the gut.

It's already there, but having more seems to be a good thing.