Aging Cell

We'll start with some potentially paradigm-shifting research on the human ovary.

According to a new study published in Aging Cell, these aren't just reproductive organs.

Long after ovaries stop producing eggs, the researchers say, the organs continue to evolve.

Building off of previous work in mice, the study examined normal ovarian tissue from 28 postmenopausal women between the ages of 50 and 75.

Researchers at Northwestern University in Chicago and Buck Institute in California have found they don't become dormant or sit in the body like an appendix doing nothing.

Their study, published Wednesday in the medical journal Aging Cell, shows ovaries get busy maintaining tissue and cell structure.

lipid metabolism, immunity and inflammation.

The researchers say it turns out that for ovaries, menopause is more like a career change than retirement.

ovaries stop releasing eggs after menopause, but their work isn't over.

Researchers at Northwestern University in Chicago and Buck Institute in California have found they don't become dormant or sit in the body like an appendix doing nothing.

Their study, published Wednesday in the medical journal Aging Cell, shows ovaries get busy maintaining tissue and cell structure.

lipid metabolism, immunity and inflammation.

Researchers reprogrammed blood cells from an 80-year-old donor into stem cells with a molecular age under 20 years.

The paper is in the journal Aging Cell, source HTTPS, doi.org's tttps12102111211, and the shorthand version, Cellular Reprogramming Didn't Just Rewind Identity, The Epigenetic Clocks Came Back Decades Younger, The cells are functionally juvenile while carrying an octogenarian's chronological origin.

Worth being precise about what this does and doesn't mean.

It does not mean anyone's biological age dropped 20 years.

Spermidine supplement may strengthen vaccine responses in older adults, a new study finds.

A study published in the journal Aging Cell suggests that spermidine, a naturally occurring compound, may improve how the immune systems of certain older adults respond to vaccination.

The proposed mechanism involves a reduction in biological markers associated with immune aging.

The age-linked decline in immune function, known as immunosenescence, can leave certain older adults with reduced protection from both age-related conditions and vaccines.

In rodents, restricting single amino acids works remarkably well.

Richard Miller and his colleagues published a study in Aging Cell in 2005, and they showed that methionine-deficient diet extended mouse lifespan, slowed immune aging as well as lens aging, and lowered serum IGF-1, insulin, glucose, and thyroid hormone, while making hepatocytes or liver cells more resistant to oxidative stress.

That is genuinely impressive results and the metabolic signature is exactly what you would predict from reduced growth signaling.

The translation problem is severe though.