4-Hydroxynonenal
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Search complete. 7 mentions across 5 episodes found for "4-Hydroxynonenal".
Nov 9, 2026
Cherie CalbomGUEST
Yes.
Anthony GuastellaHOST
My understanding, when you consume these things, they actually create a compound called 4-HNE, and it kind of has a lot of health effects.
Anthony GuastellaHOST
Is that right?
Cherie CalbomGUEST
That's a new one, so you can explain that to me.
Anthony GuastellaHOST
Yeah, 4-HNE, it's basically something that I've learned about.
Anthony GuastellaHOST
It's basically how when you consume these oils, it creates a lot more of that.
Anthony GuastellaHOST
I mean, I probably should look at it a little bit more, but it basically has the effects that we're talking about in terms of the free radical capacity and all the inflammation.
Fred GrossmanGUEST
So it's not a great marker of progression.
Fred GrossmanGUEST
What we are working with now, based on the work by Dr. Stanley Appel, is to look at 4-HNE, which is 4-hydroxynonanol.
Fred GrossmanGUEST
Big word, but it's an oxidative stress hormone.
Fred GrossmanGUEST
marker.
Eric BergHOST
It can create a lot of problems.
Eric BergHOST
One of the secondary, uh, compounds that's created, I'm not gonna get into the long name, but it's called HNE, which is a very, very toxic thing, and that can create neurodegeneration, cancer, heart disease, like we already mentioned, and inflammation.
Eric BergHOST
Now, if we compare 2010 to 2013, there's been an increase of this by 135X, so that's a major increase in our bodies.
Eric BergHOST
This particular food is made with similar machines that they make petroleum products from.
Ben BikmanGUEST
I think some people, um, refuse to acknowledge the fact that omega-6 fats can be burned, um, and they are, they are burned very readily.
Ben BikmanGUEST
Um, but that's of course at more modest amounts, where we far overwhelm the ability of the mitochondria to burn these for fuels and then they go down the route of, of creating, um, these, these radical forms, versions of themselves like 4-HNE, et cetera.
Ben BikmanGUEST
What I think, to elaborate on that point, which, which I think you should, would suggest, um, diving into the literature a little bit and look a- a- and just confirming finding evidence of omega-6 fats, and maybe just linoleic acid specifically, either directly compromising m- uh, electron transport syst- electron, um, carriers, the complexes, or affecting dynamics, like perhaps it's forcing mitochondrial fission-
Thomas P. SeagerHOST
Yeah
Ken BerryHOST
There's not any research showing any long-term negative effects to a ketogenic diet whatsoever.
Ken BerryHOST
One, increase in 4HNE.
Ken BerryHOST
Two, s-, uh, so 4HNE, you're trying to major in the minor.
Ken BerryHOST
Stop worrying about minutiae, just eat lots of natural health, healthy food.
Ken BerryHOST
Uh, I wasn't finished with that question.